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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Reactivity | Human |
| Tested applications | WB IF |
| Recommended Dilution | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Calculated MW | 43kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human FEN1 |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | e |
| Synonym | FEN1;FEN-1;MF1;RAD2 |
Flap endonuclease-1 (FEN1) is a structure-specific nuclease with multiple functions in DNA processing pathways (1,2). The replication and DNA repair activities of FEN1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers (3). FEN1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair (4,5). The multi-functional activities of FEN1 are regulated by various mechanisms, including protein partner interactions (6,7), post-translational modifications (8,9), and subcellular re-localization in response to cell cycle or DNA damage (10).
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