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Our customer service representatives are available 24 hours, Monday through Friday to assist you.| Introduction | TNNI2 is a fast-twitch skeletal muscle protein, belongs to the troponin I gene family, and is part of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, together with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. Other than muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a coactivator of estrogen receptor-related receptor alpha. Furthermore, TNNI2 suppresses tumor growth in human ovarian carcinoma. Mutations in the TNNI2 gene cause myopathy and distal arthrogryposis type 2B. |
| Synonyms | Troponin I fast skeletal muscle, Troponin I fast-twitch isoform, TNNI2, DA2B, FSSV, fsTnI, AMCD2B. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colourless liquid formualtion. |
| Formulation | The protein solution contains 20mM Tris-HCl, 500mM NaCl and 10mM b-ME, pH 7.5. |
| Stability | TNNI2 Human althoµgh stable at 10°C for 7 days, should be stored below -18°C.Please prevent freeze-thaw cycles. |
| Purity | Greater than 85.0% as determined by SDS-PAGE. |
| Usage | NeoBiolab's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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